Expression of New York esophageal squamous cell carcinoma-1 in primary and metastatic melanoma
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چکیده
منابع مشابه
Role of Brg1 in progression of esophageal squamous cell carcinoma
Objective(s): Epigenetic regulation of gene expression can be carried out through chromatin remodeling enzymes such as SWI/SNF. Brg1 also known as SMARCA4 is a catalytic subunit of SWI/SNF, which is necessary for MMPs expression. Matrix metalloproteinases (MMPs) are known as important player enzymes during tumor progression and metastasis. Aberrant epigenetic modification of chromatin should be...
متن کاملExpression analysis of CD44 isoforms S and V3, in patients with esophageal squamous cell carcinoma
Objective(s): CD44 is a member of the cell adhesion molecules family. Naturally, CD44S, along with CD44V3 influence the cell motility, migration, and adhesion, while in tumor cells they lead to tumor invasion, progression, and metastasis. The purpose of this research is to evaluate the CD44S and CD44V3 expression in Esophageal Squamous Cell Carcinoma (ESCC) and to reveal their correlations wit...
متن کاملSquamous Cell Differentiation in Metastatic Papillary Thyroid Carcinoma: Metaplastic
Squamous cell differentiation (SCD) may occur in papillary thyroid carcinoma (PTC) only at metastatic sites. We have studied cytokeratin CK5/6 and P63 along with TTF1 (thyroid transcription factor 1) and B-Raf (V-Raf murine sarcoma viral oncogene homolog B1) immunohistochemical expression in neck lymph node metastases of thyroid PTC showing SCD. The patient (21-years) presented wit...
متن کاملMastermind-like 1 (MAML-1) as a new metastatic marker in esophageal squamous cell carcinoma
Deregulation of the normal cellular processes that mediate cell proliferation, differentiation and death programs, have been seeing in various tumor cell types [1]. Notch signaling pathway that plays fundamental roles in definition of the cell fate and self-renewal is frequently deregulated in human malignancies, by up or down regulation, where it may act either as an oncogene or as a tumor sup...
متن کاملMAGE-A3/4 and NY-ESO-1 antigens expression in metastatic esophageal squamous cell carcinoma
In the present study we analyzed immunohistochemical expression of MAGE-A 3/4 and NY-ESO-1 in 55 samples of esophageal squamous cell carcinomas (ESCC) and their respective lymph node metastases. To our knowledge this is the first study to assess and compare the expression of these antigens in ESCC lymph node metastases. Fifty (90.9%) primary ESCC were positive for MAGE-A 3/4 and 53 (96.6%) were...
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ژورنال
عنوان ژورنال: Human Pathology
سال: 2014
ISSN: 0046-8177
DOI: 10.1016/j.humpath.2013.05.029